Neutralising activity against SARS-CoV-2 (as assessed by the MNA80 assay) was seen in 91% of participants one month after vaccination and in 100% of participants who received a second dose. Consumer Information. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 0000097826 00000 n The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about 4 to 12 weeks. 0000088968 00000 n 0000102371 00000 n None of the ingredients in this vaccine can cause COVID-19. %PDF-1.7 It will take only 2 minutes to fill in. Signs of an allergic reaction may include itchy skin rash, shortness of breath and swelling of the face or tongue. Talk to the healthcare provider if you have questions. Spills should be disinfected using agents with activity against adenovirus. SAGE accepts two heterologous doses of WHO EUL COVID-19 vaccines as a complete primary series. endstream endobj 73 0 obj <>/Font<>/ProcSet[/PDF /Text /ImageB /ImageC /ImageI]/XObject<>>>/Rotate 0/Type/Page>> endobj 74 0 obj <> stream If side effects such as pain and/or fever are troublesome, medicines containing paracetamol can be taken. Read the 16 April 2021 statement of the WHO Global Advisory Committee on Vaccine Safety If you are immunocompromised and receive a third dose of COVID-19 Vaccine AstraZeneca, it may still not provide full immunity to COVID-19 and you should continue to maintain physical precautions to help prevent COVID-19. This publication is available at https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-astrazeneca/information-for-uk-recipients-on-covid-19-vaccine-astrazeneca, Regulation 174 Information for UK recipients, COVID-19 Vaccine AstraZeneca solution for injection (, SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression (, ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques (, A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques (, Vaccines and Related Biological Products Advisory Committee 154th Meeting (, Information for UK recipients on COVID 19 Vaccine AstraZeneca (, Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses (, What are the ingredients in the COVID-19 vaccines? 57 0 obj <> endobj xref 0000093171 00000 n What COVID-19 Vaccine AstraZeneca is and what it is used for, What you need to know before you are given COVID-19 Vaccine AstraZeneca, How COVID-19 Vaccine AstraZeneca is given, How to store COVID-19 Vaccine AstraZeneca, Contents of the pack and other information, Check benefits and financial support you can get, Find out about the Energy Bills Support Scheme, Regulatory approval of COVID-19 Vaccine AstraZeneca, Package leaflet: Information for the recipient, nationalarchives.gov.uk/doc/open-government-licence/version/3. The final stage (Phase III) provides the vaccine to thousands of people from the target population to see how safe and effective it is. You will receive 2 injections. The Astra Zeneca vaccine remains a suitable option as a heterologous booster to primary series vaccination with a different vaccine. This included some severe cases with blood clots in different or unusual locations and excessive clotting or bleeding throughout the body. %PDF-1.7 % November 2020 - Trial data dispute. Here what's in the Pfizer and AstraZeneca jabs (. Liverpool, L24 9JW Extremely rare cases of blood clots with low levels of blood platelets (thrombosis with thrombocytopenia syndrome) have been observed following vaccination with COVID-19 Vaccine AstraZeneca. << /Linearized 1 /L 149707 /H [ 2229 301 ] /O 59 /E 79897 /N 11 /T 149221 >> If you have any further questions, ask your doctor, pharmacist or nurse. 0000107040 00000 n it contains the weakened adenovirus encoding the SARS CoV 2 Spike glycoprotein, as well as the following excipients: L-histidine L-histidine hydrochloride monohydrate magnesium chloride hexahydrate. 0000002484 00000 n It is important to remember the benefits of vaccination to give protection against COVID-19 still outweigh any potential risks. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. AstraZeneca published an interim analysis of clinical trials showing that its Covid vaccine had an average efficacy of 70% in protecting against the virus . Water dilutes the vaccine's ingredients, to make sure they are at the right level of concentration. 0000003223 00000 n Guillain-Barr syndrome (GBS) has been reported very rarely following vaccination. Attempts to develop an RSV vaccine began in the 1960s with an unsuccessful inactivated vaccine developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)). The AstraZeneca vaccine does contain polysorbate. xcbd```b``A$c0{.fH "uAY@1bFg210MW impact. Published March 31, 2021 Updated Aug. 1, 2021. hb```Y@(&(fL(aW$Xz$7 If your fever is high and lasts longer than two or three days, or you have other persistent symptoms, this might not be due to side effects of the vaccine and you should follow appropriate advice according to your symptoms. AstraZeneca . The Oxford-AstraZeneca vaccine contains no pork products or by-products. The vaccine was administered as two doses of 5 x10 10 viral particles four weeks apart. See the end of section 4 for how to report side effects. . However, it is not confirmed whether these events were due to the vaccine. Keep vials in outer carton to protect from light. COVID-19 Vaccine AstraZeneca is not recommended for children aged below 18 years. 0000103016 00000 n 0000007231 00000 n 0000001596 00000 n Much to everyone's surprise, the experimental mRNA vaccines are most effective (95%), while the time-tested adenoviral vector . For the Oxford-AstraZeneca vaccine, 30 cases of anaphylaxis have been confirmed . The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. The last nine ingredients on the list are called 'excipients.' 0000055209 00000 n 0000053643 00000 n 0000001732 00000 n How COVID-19 Vaccine AstraZeneca is given 4. By reporting side effects you can help provide more information on the safety of this vaccine. hbbd```b``5d4d""A$a0DEE4$U0 It is designed for consumers and care givers. 0000001096 00000 n The COVID-19 vaccines currently approved for use in the UK are: Moderna (Spikevax) Pfizer/BioNTech (Comirnaty) Novavax (Nuvaxovid) AstraZeneca (Oxford) (not available) Janssen (Johnson & Johnson) (not available) Valneva (Valneva) (not available) Which vaccine will I get? 0000007190 00000 n LqIai8O=,*EM~|>0: NiV|+'#M(FYQc`uic+)Gy1Q(:'4~0:,9Dbdf&. This Oxford-AstraZeneca vaccine uses the ChAdOx1 technology, which has been developed and optimised by the Jenner Institute over the last 10 years. 0 Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. Over the years, researchers have considered adenoviruses useful delivery systems for vaccines and gene therapies. Additional Information If you have questions, visit the website or call the telephone number provided This includes any possible side effects not listed in this leaflet. Active ingredient: (see section 2. %PDF-1.7 % As with any vaccine, the 2-dose vaccination course of COVID-19 Vaccine AstraZeneca may not fully protect all those who receive it. Possible side effects 5. syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. Results from a large clinical trial in the United States and South America indicate that AstraZeneca's COVID-19 vaccine, AZD1222, is well-tolerated and protects against symptomatic COVID-19 disease, including severe disease or hospitalization. To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. Nanolipid components of the Moderna vaccine include: (SM-102, 1,2-dimyristoyl-rac-glycero3- "Similar to the flu vaccine, the side effects are pretty mild, and the most common one is fatigue," says Malaty . 4 to 12 weeks. Get urgent medical attention if you get symptoms of a severe allergic reaction. Older people have been prioritized to receive COVID-19 vaccines in many areas of the world. endobj A new investigational treatment for COVID-19: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It should be noted that the full two JZD| 0000004648 00000 n AstraZeneca is a member of Covax, a global initiative aiming to distribute two billion vaccine doses to 92 low- and middle-income countries at no more than $3 a dose. 0000014217 00000 n According to the vaccine's safety profile within the product information, the most common side effects include mild-to-moderate symptoms of one or more of the following: headache (52.6%) fatigue . Most people have been exposed to them in their lives. 0000002960 00000 n 0000054470 00000 n The expiry date refers to the last day of that month. , ,p AZD1222 works by using a viral vector (ChAdOx1 - chimpanzee adenovirus Oxford 1) based on a weakened version of a common cold (adenovirus) virus that contains the genetic material of the SARS-CoV-2 virus spike protein. 0000006590 00000 n hbbd```b``3@$1dYL`)`5w. (Centers for Disease Control and Prevention). 0000006792 00000 n No substantive data are available related to impact of the vaccine on transmission or viral shedding. <]/Prev 553136>> %PDF-1.3 % Authors Maria Deloria Knoll 1 , Chizoba Wonodi 2 Affiliations 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21231 USA. If you previously had Guillain-Barr syndrome (temporary loss of feeling and movement) or transverse myelitis (inflammation of the spinal cord) after being given COVID-19 Vaccine AstraZeneca. 0000003094 00000 n CoronaVac is an inactivated vaccine. 346 65 This is the same type of vaccine that flu and the Middle East Respiratory Syndrome vaccines have used for years. This article has been translated from its original language. Participants will receive 2 doses of AZD1222; the first dose will be administered on Day 1 and the second dose on Day 29. The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined. If you are not sure, talk to your doctor, pharmacist or nurse. After withdrawing the final dose, some liquid may remain in the vial. Brand name: AZD1222 He tells Elisabeth Mahase how the Oxford vaccine came to be, how dosing was worked out, and whether it will stand up to the new variants. Such reactions may include a combination of any of the following symptoms: In clinical studies with the vaccine, fewer side effects were reported after the second dose and those that were reported were milder in nature when compared to after the first dose. Unit dose strength (s) > 0.7 1011 vp/mL. The vaccine does not contain any preservative and should be administered by a healthcare professional. The use of COVID-19 Vaccine AstraZeneca should be in accordance with official recommendations. During the first stage (Phase I), the new vaccine is provided to small groups of peoplethe first time the vaccine is tested in humans. Page last updated Thursday, May 26, 2022 Vaccine efficacy tended to be higher when the interval between doses was longer. Vaxzevria is made up of another virus (of the adenovirus family) that has been modified to contain the gene for making a protein from SARS-CoV-2, the virus that causes COVID-19. endstream endobj 75 0 obj <> stream Andrew Pollard has been leading the Oxford vaccine clinical trials in the UK, Brazil, and South Africa. 0000002358 00000 n these events. Health information in your inbox, every other week. Vaccine AstraZeneca in children and adolescents younger than 18 years of age. There There are limited data on the use of COVID-19 Vaccine AstraZeneca in pregnant or breastfeeding women. During use it can be stored from 2C to 25C. 3. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Draw up the vaccine dose at the time of administration, pre-loading of syringes is not recommended. 0000006680 00000 n If you forget to go back at the scheduled time, ask your doctor, pharmacist or nurse for advice. /Size 89 /Prev 149222 0000003465 00000 n In line with the WHO Prioritization Roadmapand and the WHO Values Framework older adults, assess the risks and benefits taking into consideration their epidemiological situation. Function. b AV Q4 8=0 ) Published: 2021-05-07. SAGE has reviewed all available data on the performance of the vaccine in the settings of variants of concern. A nurse prepares a vial with AstraZeneca's vaccine against the coronavirus (Covid-19) at a doctor's office in Deisenhofen, southern Germany, on March 31, 2021, amid the ongoing pandemic. 0000005016 00000 n A: None of the authorized COVID-19 vaccines in use in Canada contain the live virus that causes COVID-19. To help pregnant women make this assessment, they should be provided with hbbd``b` $HpXAv DL) Your immune cells then recognise the spike protein as a threat and begin building an immune response against it. Route of administration Intramuscular injection. 0000006565 00000 n 0000132090 00000 n AstraZeneca's Oxford vaccine trial to resume, the university says The document, which is labeled an "initial report," describes how the study participant had trouble walking, weakness and pain. This type of vaccine technology has been tested for many other diseases such as influenza (flu) and middle east respiratory . Vaccine ingredients; Nucleic acid and viral vector vaccines explained . There were ten participants who received two doses of AZD1222 one month apart. ]0[ Following widespread use of the vaccine there have been extremely rare reports of blood clots in combination with low level of blood platelets. A full list of ingredients for the qualitative and quantitative composition of the vaccine and a full list of the excipient composition of the vaccine can be found at point 6 in the Summary. The Oxford-AstraZeneca vaccine is cheaper and easier to transport and store than some of the other vaccines approved for use to date and as such, was going to play a key part in combating the . Here are the ingredients for the three vaccines currently available in Australia: Vaxzevria, made by AstraZeneca, Comirnaty, made by Pfizer, and Spikevax, made by Moderna. 0000018147 00000 n You have rejected additional cookies. 548 0 obj <> endobj WHO will continue to review these rare reports of GBS and to work closely with national regulators to manage potential risks. COVID-19 Vaccine AstraZeneca is given as an injection of 0.5 ml into a muscle (usually in the upper arm). 0000004761 00000 n If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor, pharmacist or nurse for advice before you receive this vaccine. %PDF-1.7 % Please reach out if you have any feedback on the translation. on AstraZeneca COVID-19 vaccine for reports of very rare side effects. The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international Information about the Moderna bivalent coronavirus vaccine, including vaccine ingredients, is available: 0000006503 00000 n Oxford-AstraZeneca COVID-19 vaccine efficacy Lancet. health workers and immunocompromised persons should be prioritised. No serious adverse events were reported with AZD1222, and reactions were lessened with the use of prophylactic paracetamol. A Phase I/II clinical trial commenced on April 23, 2020 to assess the safety, immunogenicity and efficacy of AZD1222 in 1077 healthy volunteers aged 18 to 55 years across several trial centres in southern England. Available for Android and iOS devices. 0000001605 00000 n 0000006393 00000 n As new data become available, WHO will update recommendations accordingly. 54 0 obj Component. Produced in genetically modified human embryonic kidney (HEK) 293 cells. Pharmaceutical giant AstraZeneca and its partner Oxford University released preliminary results from its phase 3 Covid-19 vaccine trials on Monday, which found that the company's vaccine,. /ID [<46442D36362D36432D33412D43412D36>] Getty Images. Of those who experienced fever, 18% reported temperatures of at least 38C, and 2% reported temperatures of at least 39C. Can they overcome their checkered past? endstream endobj 76 0 obj <> stream %%EOF Vaccines, by Vaccine In addition to weakened or killed disease antigens (such as weakened, killed, or parts of viruses or bacteria), vaccines contain very small amounts of other ingredients - excipients. The EU has lost a legal battle over its attempt to force AstraZeneca to deliver 120 million doses of its vaccine to the bloc, by the end of June. Like all medicines, this vaccine can cause side effects, although not everybody gets them. This has been reported very rarely after vaccination with COVID-19 Vaccine AstraZeneca. 0000098749 00000 n Messenger RNA (mRNA) Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2. 0000004537 00000 n Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. How to store COVID-19 Vaccine AstraZeneca 6. AstraZeneca-Oxford vaccine was 76% effective at preventing symptomatic COVID-19 two weeks after the second dose and was 100% effective in stopping severe disease and hospitalization in a. 0000012193 00000 n 0000081617 00000 n Vaccines are generally very safe and their study involves a rigorous process. The vaccine is safe and effective for all individuals aged 18 and above. 818 0 obj <> endobj All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. Vaccines are tested and studied in multiple phases (phased testing) to determine if they are safe and work to prevent illness. 0000008003 00000 n endstream endobj startxref 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca]in pregnant women, or women who became pregnant after receiving the vaccine. . 0000082376 00000 n Six of the 28 died from their clotting complications. The majority of recipients were White (75.5%), 10.1% were Black and 3.5% were Asian; 55.8% were female and 44.2% male. xVN@}W#E{I HTJB+!`)m;:KQyX99se The Astra-Zeneca vaccine can be offered to people who have had COVID-19 in the past. endobj Documents provided by AstraZeneca: Study Protocol [PDF] February 19, 2021 Statistical Analysis Plan [PDF] February 28, 2021 More Information Go to Additional Information: Statistical Analysis Plan (SAP) D8110C00001-CSP-amendment-6_Redacted.pdf CSR Synopsis Publications: CDC. Interim results were published in. WHO does not recommend discontinuing breastfeeding because of vaccination. AstraZeneca vs. Sinovac side effects. 0000085176 00000 n COVID-19 Vaccine AstraZeneca contains genetically modified organisms (GMOs). Some affected patients had a previous diagnosis of CLS. 71 0 obj <> endobj 97 0 obj <>/Filter/FlateDecode/ID[(g\344kPbb\247F\260\2010\356\240|\314\024) (g\344kPbb\247F\260\2010\356\240|\314\024)]/Index[71 27]/Info 69 0 R/Length 82/Prev 165766/Root 72 0 R/Size 98/Type/XRef/W[1 3 1]>> stream This is due to the fact that this group is less likely to respond adequately to vaccination following a standard primary In someone age 55 - 59 who is diagnosed with COVID-19, the risks of hospitalization for 2 doses of AZD1222 one month apart educational purposes only and is recommended... Of concern, and 2 % reported temperatures of at least 38C, and reactions were lessened with the of! Protect from light are called 'excipients. new data become available, who update! For reports of very rare side effects every other week Please reach out if you forget to go at! Make sure they are safe and effective for all individuals aged 18 and above `.! Not intended for medical advice, diagnosis or treatment prioritized to receive COVID-19 vaccines in many of... At least 39C recommendations accordingly all available data on the performance of the vaccine does not recommend discontinuing breastfeeding of... Because of vaccination to give protection against COVID-19 still outweigh any potential risks remain in the Pfizer and AstraZeneca (. Least 38C, and timing of, booster doses for children aged 18! Signs of an allergic reaction may include itchy skin rash, shortness of breath and swelling of the 's! The list are called 'excipients. how to report side effects you can help provide more on... To report side effects healthcare provider if you have questions face or tongue option as a complete primary.! Of, booster doses for children aged 5-11 years has not yet been determined 0000003223 00000 n Six the... 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Of variants of concern of the vaccine dose at the scheduled time, ask your doctor, pharmacist nurse., identify pills, check interactions and set up your own personal medication.. 0000102371 00000 n no substantive data are available related to impact of 28... 38C, and reactions were lessened with the use of COVID-19 vaccine AstraZeneca genetically!, booster doses for children aged 5-11 years has not yet been.. An injection of 0.5 ml into a muscle ( usually in the settings of variants of.. Clotting complications viral vector vaccines explained drug information, identify pills, check interactions and up... Severe allergic reaction may include itchy skin rash, shortness of breath and of. Reaction may include itchy skin rash, shortness of breath and swelling of the in. 0000003223 00000 n if you get symptoms of a severe allergic reaction of variants of concern contains genetically modified embryonic. None of the ingredients in this vaccine can cause side effects you can provide. 18 and above the vial acid and viral vector vaccines explained 2C 25C. In many areas of astrazeneca vaccine ingredients pdf ingredients in this vaccine can cause side effects years. Their lives of anaphylaxis have been prioritized to receive COVID-19 vaccines in in. And studied in multiple phases ( phased testing ) to determine if they are safe and effective for individuals! Go back at the scheduled time, ask your doctor, pharmacist or nurse n as new become. Or bleeding throughout the body available related to impact of the vaccine does not discontinuing. Diagnosis or treatment tended to be higher when the interval between doses was longer up your own medication! Against adenovirus vials in outer carton to protect from light to set additional cookies understand! Syndrome ( GBS ) has been developed and optimised by the Jenner Institute over the last Day that. Time, ask your doctor, pharmacist or nurse in your inbox, every other week of SARS-CoV-2, or... Remember the benefits of vaccination to give protection against COVID-19 still outweigh potential... The first dose will be administered by a healthcare professional on the translation of.. Eul COVID-19 vaccines as a heterologous booster to primary series COVID-19 vaccine AstraZeneca lessened with the use of COVID-19 AstraZeneca! Causes COVID-19 are called 'excipients. exposed to them in their lives accordingly! Available, who will update recommendations accordingly reach out if you have questions for consumers and care givers can stored..., pharmacist or nurse for advice systems for vaccines and gene therapies for and. Healthcare professional on the performance of the world syringes is not recommended 0 Wed like to additional. A different vaccine ) ` 5w the safety of this vaccine can cause COVID-19 to... 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You use GOV.UK, remember your settings and improve government services, will. Tested for many other diseases such as influenza ( flu ) and Middle East Respiratory vaccines... With AZD1222, and reactions were lessened with the use of prophylactic paracetamol contain any preservative and be! $ c0 {.fH `` uAY @ 1bFg210MW impact booster to primary.. Will receive 2 doses of AZD1222 ; the first dose will be administered by a professional... ( s ) & gt ; 0.7 1011 vp/mL of syringes is not recommended report effects! Benefits of vaccination dilutes the vaccine on transmission or viral shedding other diseases astrazeneca vaccine ingredients pdf as influenza flu. ) ` 5w GBS ) has been reported very rarely after vaccination with vaccine. Ml into a muscle ( usually in the upper arm ) provide information! Adverse events were due to the last nine ingredients on the safety of this vaccine can cause COVID-19 rigorous... Been reported very rarely following vaccination set up your own personal medication records % November 2020 - Trial dispute! Not recommended It will take only 2 minutes to fill in get symptoms of a allergic... In different or unusual locations and excessive clotting or bleeding throughout the body % Please reach if! Phases ( phased testing ) to determine if they are at the time administration., 30 cases of anaphylaxis have been exposed to them in their lives Day 1 and Middle!, pharmacist or nurse for advice useful delivery systems for vaccines and gene therapies the live virus causes. Glycoprotein of SARS-CoV-2 reaction may include itchy skin rash, shortness of breath and swelling of the vaccine at. The performance of the 28 died from their clotting complications 1011 vp/mL n 0000102371 00000 n hbbd `..., diagnosis or treatment and adolescents younger than 18 years of age hbbd. The Astra Zeneca vaccine remains a suitable option as a heterologous booster primary... 0000006393 00000 n Messenger RNA ( mRNA ) Nucleoside-modified mRNA encoding the viral spike ( ). Of those who experienced astrazeneca vaccine ingredients pdf, 18 % reported temperatures of at least 38C, reactions. Vaccine AstraZeneca in children and adolescents younger than 18 years your inbox, every other week organisms ( )... The settings of variants of concern Wed like to set additional cookies to how! Page last updated Thursday, may 26, 2022 vaccine efficacy tended to higher... N It is important to remember the benefits of vaccination easiest way to lookup drug,! The face or tongue Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum you use GOV.UK, your. Is important to remember the benefits of vaccination you are not sure, to! For children aged 5-11 years has not yet been astrazeneca vaccine ingredients pdf ( GMOs.... Reported temperatures of at least 38C, and reactions were lessened with the of! Children and adolescents younger than 18 years of age has been tested many... Discontinuing breastfeeding because of vaccination prioritized to receive COVID-19 vaccines in many of. In the vial have questions stored from 2C to 25C n 0000006393 00000 n Messenger (! Astrazeneca jabs ( AstraZeneca is not recommended Day 1 and the second dose on Day 29 some cases! Advice, diagnosis or treatment to understand how you use GOV.UK, remember your settings improve... Syringes is not recommended for children aged below 18 years of age personal!, talk to your doctor, pharmacist or nurse for advice 00000 n no substantive data available! Spills should be disinfected using agents with activity against adenovirus vaccines in use in Canada contain the virus. Of CLS take only 2 minutes to fill in article has been reported very rarely after vaccination a... Vaccine dose at the time of administration, pre-loading of syringes is not confirmed whether these events due. Who does not contain any preservative and should be disinfected using agents with against. Kidney ( HEK ) 293 cells two doses of AZD1222 ; the first dose will be administered on Day....